Sironax is an emerging leader in the discovery and development of novel therapies for neurodegenerative, inflammatory and immunological, metabolic, and rare diseases.

Emerging Leader
Blood Brain Barrier

Founded in 2017 by Dr. Xiaodong Wang and Dr. Zhiyuan Zhang, Sironax has built a diverse pipeline of programs by targeting contributors of aging, degeneration, metabolic dysfunction, and inflammation. We are conducting clinical studies with SARM1 inhibitor SIR2501, NAMPT activator SIR4156, and RIPK1 inhibitor SIR9900, in addition to our ongoing preclinical research.

With operations in the United States, China, Switzerland, and Australia, Sironax has a growing global team of more than 170 employees. Our team, with decades of global pharmaceutical R&D experience, shares a vision of shifting the treatment paradigm to ultimately improve the lives of millions of patients worldwide.

A History of Innovation and Development

2017

Sironax founded (Cayman Islands)

2018

Established R&D facility in Beijing

2019

Established clinical operations in Australia; Secured Series A funding

2021

Opened research facility in Shanghai

2022

Secured Series B funding

Nominated brain penetrant RIPK1 inhibitor SIR9900 preclinical candidate

2023

Nominated first in class allosteric SARM1 inhibitor SIR2501 preclinical candidate

Completed SIR9900 Phase 1 in healthy volunteers

2024

Nominated first in class NAMPT activator SIR4156 preclinical candidate

Completed SIR2501 Phase 1 in healthy volunteers

2025

Established HQ in U.S. & European operations in Switzerland

Formed strategic asset agreement with Novartis

Initiated SIR2501 Phase 1b/2 patient study

Completed SIR4156 Phase 1 in healthy volunteers

2026

Advancing SIR2501, SIR4156, and SIR9900 Phase 1b/2 studies

Corporate milestones
Clinical milestones
Author: Al MacDonald Editor: Fritz Lekschas License: CC BY-SA 3.0 ID: ISO 3166-1 or "_[a-zA-Z]" if an ISO code is not available

Mission

We are an emerging leader at the forefront of innovating transformative therapies that address diseases affecting longevity, diseases requiring supportive care, certain rare diseases, and inflammatory and immunology diseases.

Meet Our Team

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