WALTHAM, Mass., Oct. 29, 2026 – Sironax, a global clinical-stage biotechnology company developing transformative therapies for neurodegenerative, inflammatory and immunologic, metabolic, and rare diseases, today announced the selection of three abstracts on its SARM1 Inhibitor SIR2501 for presentation in poster sessions at Neuroscience 2026, the Society for Neuroscience annual meeting, from November 14 to 18 at the Walter E. Washington Convention Center in Washington, DC.
Presentation details are below:
Title: SIR2501, a Novel SARM1 Inhibitor, Demonstrates Favorable Safety and Early Evidence of Biological Activity in Patients with Amyotrophic Lateral Sclerosis
Session: ALS and Motor Neuron Diseases: Therapeutics
Session Number: PSTR091
Date/Time: November 15, 1-5 p.m. EST
Title: Neuroprotective Effects of SIR2501, an Allosteric SARM1 Inhibitor, in Preclinical Studies of ALS, Glaucoma, and Ischemic Stroke
Session: ALS and Motor Neuron Diseases: Therapeutics
Session Number: PSTR091
Date/Time: November 15, 1-5 p.m. EST
Title: SIR2501, a Novel SARM1 Inhibitor, Demonstrates Favorable Safety, Predictable Pharmacokinetics, and Early Signals of Protection Against Chemotherapy-Induced Peripheral Neuropathy
Session: Peripheral Nerve Damage, Neuropathic Pain, and Repair
Session Number: PSTR357
Date/Time: November 18, 1-5 p.m. EST
About SIR2501
SIR2501 is a first-in-class allosteric inhibitor of SARM1, a key driver of nerve damage in diseases such as amyotrophic lateral sclerosis (ALS) and chemotherapy-induced peripheral neuropathy (CIPN), for which it was granted Fast Track designation by the FDA. By binding SARM1 away from its active site and maintaining the enzyme in an inactive state, SIR2501 is designed to protect nerves and prevent degeneration, while avoiding potential adverse effects observed with orthosteric inhibitors. SIR2501 has demonstrated strong neuroprotective effects in multiple preclinical models, and global Phase 1b/2 clinical trials evaluating SIR2501 in patients with ALS and CIPN are ongoing.
Forward-Looking Statements
SIR2501 is an investigational product candidate and has not been approved by the FDA or any other regulatory authority. Preclinical results may not be predictive of clinical outcomes. The safety and efficacy of SIR2501 in humans have not yet been established.
About Sironax
Headquartered in Waltham, Massachusetts, Sironax is a global clinical-stage biotechnology company developing transformative therapies for neurodegenerative, inflammatory and immunologic, metabolic, and rare diseases. The company has built a diverse pipeline of programs by targeting contributors of aging: degeneration, metabolic dysfunction, and inflammation. In addition to SARM1 inhibitor SIR2501, Sironax is conducting clinical studies with NAMPT activator SIR4156 and RIPK1 inhibitor SIR9900, as well as ongoing preclinical research. The company was recently named to Fierce Biotech’s “Fierce 15” list of the most innovative and promising private biotechs of 2026. For more information, visit sironax.com.